Case C-15/10: Judgment of the Court (Fourth Chamber) of 21 July 2011 (reference for a preliminary ruling from the High Court of Justice of England and Wales, Queen’s Bench Division (Administrative Court)) — Etimine SA v Secretary of State for Work and Pensions (Environment and protection of human health — Directive 67/548/EEC — Regulation (EC) No 1272/2008 — Borate substances — Classification as reprotoxic substances in category 2 — Directive 2008/58/EC and Regulation (EC) No 790/2009 — Adaptation of the classifications to technical and scientific progress — Validity — Methods of assessing the intrinsic properties of those substances — Manifest error of assessment — Legal basis — Obligation to state reasons — Principle of proportionality)