L_202402492SL.000101.fmx.xml

UREDBA KOMISIJE (EU) 2024/2492

z dne 23. septembra 2024

o spremembi Uredbe (ES) št. 440/2008 glede testnih metod zaradi njihove prilagoditve tehničnemu napredku

(Besedilo velja za EGP)

EVROPSKA KOMISIJA JE –

ob upoštevanju Pogodbe o delovanju Evropske unije,

ob upoštevanju Uredbe (ES) št. 1907/2006 Evropskega parlamenta in Sveta z dne 18. decembra 2006 o registraciji, evalvaciji, avtorizaciji in omejevanju kemikalij (REACH) ter o ustanovitvi Evropske agencije za kemikalije in o spremembi Direktive 1999/45/ES ter o razveljavitvi Uredbe Sveta (EGS) št. 793/93 in Uredbe Komisije (ES) št. 1488/94 ter Direktive Sveta 76/769/EGS in direktiv Komisije 91/155/EGS, 93/67/EGS, 93/105/ES in 2000/21/ES (1) in zlasti člena 13(2) Uredbe,

ob upoštevanju naslednjega:

(1)	Priloga k Uredbi Komisije (ES) št. 440/2008 (2) vsebuje testne metode, ki so priznane kot primerne za pridobivanje informacij o fizikalno-kemijskih, toksikoloških in ekotoksikoloških lastnostih snovi za namene Uredbe (ES) št. 1907/2006.

(2)	Organizacija za gospodarsko sodelovanje in razvoj (OECD) razvija harmonizirane in mednarodno dogovorjene smernice za preskušanje kemikalij za regulativne namene. OECD redno izdaja nove in revidirane smernice za preskušanje ob upoštevanju znanstvenega napredka na tem področju.

(3)

Da bi bila Uredba (ES) št. 440/2008 v koraku s tehničnim napredkom in da bi se v poskusne namene uporabilo manj živali, kar je tudi skladno z Direktivo 2010/63/EU Evropskega parlamenta in Sveta (3), bi bilo treba v Prilogo k Uredbi (ES) št. 440/2008 dodati sedem testnih metod: novo testno metodo za osnovne fizikalno-kemijske lastnosti (4), eno novo in dve posodobljeni testni metodi za ugotavljanje učinkov na zdravje ljudi, ki se nanašajo na teste in vitro za ugotavljanje imunotoksičnosti in preobčutljivosti kože (5), ter tri posodobljene testne metode za oceno strupenosti za okolje (6).

(4)

Poleg tega je OECD leta 2023 izdal nove popravljene različice naslednjih testnih metod, ki so bile vključene v Uredbo (ES) št. 440/2008: OECD Test Guideline 125 (7); OECD Test Guideline 316 (8); OECD Test Guideline 405 (9); OECD Test Guideline 437 (10); OECD Test Guideline 438 (11); OECD Test Guideline 456 (12); OECD Test Guideline 458 (13); OECD Test Guideline 460 (14); OECD Test Guideline 487 (15); OECD Test Guideline 491 (16); OECD Test Guideline 492 (17); OECD Test Guideline 496 (18); OECD Test Guideline 497 (19); OECD Test Guideline 498 (20). Zato je primerno zastarele različice popolnih opisov navedenih testnih metod črtati iz delov B in C Priloge k Uredbi (ES) št. 440/2008.

(5)

Za boljšo usklajenost s področno zakonodajo, zlasti z Uredbo (ES) št. 1272/2008 Evropskega parlamenta in Sveta (21), bi bilo treba preurediti seznam testnih metod za fizikalno-kemijske lastnosti v tabeli 1 v delu 0 Priloge k Uredbi (ES) št. 440/2008 ter nanj dodati relevantne testne metode: ASTM D4359-90: Standard Test Method for Determining whether a Material Is a Liquid or a Solid; Test for determining fluidity according to section 2.3.4 of Annex A of the Agreement concerning the International Carriage of Dangerous Goods by Road (ADR); Calorimetric test methods according to section 20.3.3.3 of Part II of the UN Manual of Tests and Criteria; DIN 66137-2 - Determination of solid state density - Part 2: Gas pycnometry; ISO 12154- Determination of density by volumetric displacement - Skeleton density by gas pycnometry; ISO/TR 14187:2020 - Surface chemical analysis -Characterization of nanostructured materials; EN 17199-1:2019 – Workplace exposure - Measurement of dustiness of bulk materials that contain or release respirable NOAA and other respirable particles; EN 15051-1: Workplace exposure - Measurement of the dustiness of bulk materials - Part 1: Requirements and choice of test methods; EN 15051-2: Workplace exposure - Measurement of the dustiness of bulk materials - Part 2: Rotating drum method; EN 15051-3: Workplace exposure - Measurement of the dustiness of bulk materials - Part 3: Continuous drop method; naslednje testne metode, kot so določene v Prilogi I, del 2, Uredbe (ES) št. 1272/2008 Evropskega parlamenta in Sveta: testna metoda za piroforne pline (22); testna metoda za kemijsko nestabilnost (23); testne metode za določanje začetnega vrelišča vnetljivih tekočin (24); testne metode za določanje plamenišča vnetljivih tekočin (25); testna metoda za samorektivne snovi (26); testne metode za organske perokside (27); testna metoda za jedke snovi za kovine (28) in testne metode za desenzibilizirane eksplozive (29).

(6)	Uredbo (ES) št. 440/2008 bi bilo treba zato ustrezno spremeniti.

(7)	O predlagani spremembi so bila opravljena posvetovanja z deležniki.

(8)	Ukrepi iz te uredbe so skladni z mnenjem odbora, ustanovljenega v skladu s členom 133(1) Uredbe (ES) št. 1907/2006 –

SPREJELA NASLEDNJO UREDBO:

Člen 1

Priloga k Uredbi (ES) št. 440/2008 se spremeni v skladu s Prilogo k tej uredbi.

Člen 2

Ta uredba začne veljati dvajseti dan po objavi v Uradnem listu Evropske unije.

Ta uredba je v celoti zavezujoča in se neposredno uporablja v vseh državah članicah.

V Bruslju, 23. septembra 2024

Za Komisijo

predsednica

Ursula VON DER LEYEN

(1) UL L 396, 30.12.2006, str. 1, ELI: http://data.europa.eu/eli/reg/2006/1907/oj.

(2) Uredba Komisije (ES) št. 440/2008 z dne 30. maja 2008 o določitvi testnih metod v skladu z Uredbo (ES) št. 1907/2006 Evropskega parlamenta in Sveta o registraciji, evalvaciji, avtorizaciji in omejevanju kemikalij (REACH) (UL L 142, 31.5.2008, str. 1, ELI: http://data.europa.eu/eli/reg/2008/440/oj).

(3) Direktiva 2010/63/EU Evropskega parlamenta in Sveta z dne 22. septembra 2010 o zaščiti živali, ki se uporabljajo v znanstvene namene (UL L 276, 20.10.2010, str. 33, ELI: http://data.europa.eu/eli/dir/2010/63/oj).

(4) OECD Test Guideline 126: Determination of the Hydrophobicity Index of Nanomaterials Through an Affinity Measurement (2023), https://doi.org/10.1787/ae9c0fd1-en.

(5) OECD Test Guideline 444 A: In Vitro Immunotoxicity: IL-2 Luc Assay (2023) https://doi.org/10.1787/27b10ba3-en; OECD Test Guideline 442C: In Chemico Skin Sensitisation: Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins (2023) https://doi.org/10.1787/9789264229709-en; OECD Test Guideline 442E: In Vitro Skin Sensitisation: In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation (2023), https://doi.org/10.1787/9789264264359-en.

(6) OECD Test Guideline 240: Medaka Extended One Generation Reproduction Test (MEOGRT) (2023) https://doi.org/10.1787/9789264242258-en; OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment (2023) https://doi.org/10.1787/9789264070264-en; OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Using Spiked Water (2023) https://doi.org/10.1787/9789264070288-en.

(7) OECD Test Guideline 125: Nanomaterial Particle Size and Size Distribution of Nanomaterials (2023) https://doi.org/10.1787/af5f9bda-en.

(8) OECD Test Guideline 316: Phototransformation of Chemicals in Water – Direct Photolysis (2023) https://doi.org/10.1787/9789264067585-en.

(9) OECD Test Guideline 405: Acute Eye Irritation/Corrosion (2023 https://doi.org/10.1787/9789264185333-en).

(10) OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023), https://doi.org/10.1787/9789264203846-en.

(11) OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023) https://doi.org/10.1787/9789264203860-en.

(12) OECD Test Guideline 456: H295R Steroidogenesis Assay (2023), https://doi.org/10.1787/9789264122642-en.

(13) OECD Test Guideline 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals (2023), https://doi.org/10.1787/9789264264366-en.

(14) OECD Test Guideline 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants (2023), https://doi.org/10.1787/9789264185401-en.

(15) OECD Test Guideline 487: In Vitro Mammalian Cell Micronucleus Test (2023), https://doi.org/10.1787/9789264264861-en.

(16) OECD Test Guideline 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023), https://doi.org/10.1787/9789264242432-en.

(17) OECD Test Guideline 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage (2023), https://doi.org/10.1787/9789264242548-en.

(18) OECD Test Guideline 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023), https://doi.org/10.1787/970e5cd9-en.

(19) OECD Test Guideline 497: Defined Approaches on Skin Sensitisation (2023), https://doi.org/10.1787/b92879a4-en.

(20) OECD Test Guideline 498: In vitro Phototoxicity - Reconstructed Human Epidermis Phototoxicity test method (2023), https://doi.org/10.1787/7b2f9ea0-en.

(21) Uredba (ES) št. 1272/2008 Evropskega parlamenta in Sveta z dne 16. decembra 2008 o razvrščanju, označevanju in pakiranju snovi ter zmesi, o spremembi in razveljavitvi direktiv 67/548/EGS in 1999/45/ES ter spremembi Uredbe (ES) št. 1907/2006 (UL L 353, 31.12.2008, str. 1, ELI: http://data.europa.eu/eli/reg/2008/1272/oj).

(22) Oddelek 2.2.4.2 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(23) Oddelek 2.2.4.4 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(24) Oddelek 2.6.4 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(25) Oddelek 2.6.4.4 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(26) Oddelek 2.8.4.1 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(27) Oddelek 2.15.4.1 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(28) Oddelek 2.16.2.1 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

(29) Oddelek 2.17.2.1, točki (b) in (c), in oddelek 2.17.2.2 Priloge I, del 2, Uredbe (ES) št. 1272/2008.

PRILOGA

Priloga k Uredbi (ES) št. 440/2008 se spremeni:

(1)

del 0 se spremeni:

(a)

tabela 1 se nadomesti z naslednjim:

„TABELA 1: TESTNE METODE ZA FIZIKALNO-KEMIJSKE LASTNOSTI SNOVI

Osnovne fizikalno-kemijske lastnosti
Končna točka	Testna metoda	Ustrezno poglavje s popolnim opisom testne metode v delu A te priloge (številke v oklepajih pomenijo, da je bil popolni opis testne metode črtan iz dela A; prazno okence: v delu A te priloge ni ustrezne testne metode)
Tališče/ledišče	OECD Test Guideline 102: Melting Point/Melting Range (1995)	A.1
	ASTM D4359-90: Standard Test Method for Determining whether a Material Is a Liquid or a Solid
	Test for determining fluidity according to section 2.3.4 of Annex A of the Agreement concerning the International Carriage of Dangerous Goods by Road (ADR)
Vrelišče	OECD Test Guideline 103: Boiling point (1995)	A.2
Vrelišče	Test methods according to Table 2.6.4 of Annex I, Part 2 of Regulation (EC) No 1272/2008
Vnetljivost	EN 15188:2020 – Determination of the spontaneous ignition behaviour of dust accumulations
Spodnja in zgornja meja eksplozivnosti	Test methods according to section 2.2.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 (ISO 10156 and EN 1839)
Plamenišče	Test methods according to Table 2.6.3 of Annex I, Part 2 of Regulation (EC) No 1272/2008
Temperatura samovžiga (tekočine, plini)	ISO/IEC 80079-20-1:2017 – Explosive atmospheres – Part 20-1: Material characteristics for gas and vapour classification – Test methods and data
Temperatura razgradnje	Calorimetric test methods according to section 20.3.3.3 of Part II of the UN Manual of Tests and Criteria
Temperatura razgradnje	Test Series H, part II, section 28, of the UN Manual of Tests and Criteria for the self-accelerating decomposition temperature (SADT) (with reference to a specific package)
pH	OECD Test Guideline 122: Determination of pH, Acidity and Alkalinity (2013)
Kinematična viskoznost	OECD Test Guideline 114: Viscosity of Liquids (2012)
Topnost v vodi	OECD Test Guideline 105: Water Solubility (1995)	A.6
Porazdelitveni koeficient n-oktanol/voda	OECD Test Guideline 107: Partition Coefficient (n-octanol/water): Shake-Flask Method (1995)	(A.8)
	OECD Test Guideline 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method (2022)	A.23
	OECD Test Guideline 117: Partition Coefficient (n-octanol/water): HPLC Method (2022)	A.24
Parni tlak	OECD Test Guideline 104: Vapour Pressure (2006)	(A.4)
Gostota/relativna gostota	OECD Test Guideline 109: Density of Liquids and solids (2012)	(A.3)
	DIN 66137-2 – Determination of solid state density – Part 2: Gas pycnometry
	ISO 12154 – Determination of density by volumetric displacement – Skeleton density by gas pycnometry
Lastnosti delcev	EU test method A.22. Length Weighted Geometric Mean Diameter of Fibres	A.22
	ISO 21501 – Determination of Particle Size Distribution – Single Particle Light Interaction Methods
	OECD Test Guideline 124: Determination of the Volume Specific Surface Area of Manufactured Nanomaterials (2022)
	OECD Test Guideline 125: Particle Size and Particle Size Distribution of Nanomaterials (2023)
	ISO/TR 14187:2020 – Surface chemical analysis – Characterization of nanostructured materials
Prašnost (za nanooblike snovi)	EN 17199-1:2019 – Workplace exposure – Measurement of dustiness of bulk materials that contain or release respirable NOAA and other respirable particles
	EN 15051-1: Workplace exposure – Measurement of the dustiness of bulk materials – Part 1: Requirements and choice of test methods
	EN 15051-2: Workplace exposure – Measurement of the dustiness of bulk materials – Part 2: Rotating drum method
	EN 15051-3: Workplace exposure – Measurement of the dustiness of bulk materials – Part 3: Continuous drop method
Površinska napetost	OECD Test Guideline 115: Surface Tension of Aqueous Solutions (1995)	A.5
Disociacijska konstanta	OECD Test Guideline 112: Dissociation Constants in Water (1981)	A.25
Hidrofobnost	OECD Test Guideline 126: Determination of the Hydrophobicity Index of Manufactured Nanomaterials Through an Affinity Measurement (2023)
Nevarne fizikalno-kemijske lastnosti
Eksplozivi	Test methods for explosives according to section 2.1.2.1. and 2.1.2.3. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Eksplozivi	EU Test method A.14 Explosive Properties	A.14
Vnetljivi plini	Test method for the fundamental burning velocity according to section 2.2.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
	Test method for pyrophoric gases according to section 2.2.4.2. of Annex I, Part 2 of Regulation (EC) No 1272/2008
	Test method for the chemical instability according to section 2.2.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Oksidativni plini	Test method for oxidising gases according to section 2.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Vnetljive tekočine	Test method for the sustained combustibility according to section 2.6.4.5. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Vnetljive tekočine	Test methods for determining the flash point of flammable liquids according to section 2.6.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Vnetljive trdne snovi	Test method for flammable solids according to section 2.7.2.3. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Samoreaktivne snovi	Test method for self-reactive substances according to section 2.8.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Piroforne tekočine	Test method for pyrophoric liquids according to section 2.9.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Piroforne trdne snovi	Test method for pyrophoric solids according to section 2.10.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008,
Samosegrevajoče se snovi	Test method for self-heating substances according to section 2.11.2.2. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Snovi, ki v stiku z vodo oddajajo vnetljive pline	Test method for substances which in contact with water emit flammable gases according to section 2.12.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Oksidativne tekočine	Test method for oxidising liquids according to section 2.13.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Oksidativne trdne snovi	Test method for oxidising solids according to section 2.14.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Organski peroksidi	Test methods according to section 2.15.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Jedko za kovine	Test method for substances corrosive to metals according to section 2.16.2.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Desenzibilizirani eksplozivi	Test methods according to section 2.17.2.1. (b) and (c) and according to section 2.17.2.2. of Annex I, Part 2 of Regulation (EC) No 1272/2008
Lastnosti polimerov	OECD Test Guideline 118: Determination of the Number-Average Molecular Weight and the Molecular Weight Distribution of Polymers using Gel Permeation Chromatography (1996)	A.18
	OECD Test Guideline 119: Determination of the Low Molecular Weight Content of a Polymer Using Gel Permeation Chromatography (1996)	A.19
	OECD Test Guideline 120: Solution/Extraction Behaviour of Polymers in Water (2000)	(A.20)“

(b)

tabela 2 se spremeni:

(i)

vnos „Huda poškodba oči/draženje oči“ se nadomesti z naslednjim:

„Huda poškodba oči/draženje oči	In vitro:
	OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023)	(B.47)
	OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023)	(B.48)
	OECD Test Guideline 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants (2023)	(B.61)
	OECD Test Guideline 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023)	(B.68)
	OECD Test Guideline 492: Reconstructed human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (2023)	(B.69)
	OECD Test Guideline 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification (2022)
	OECD Test Guideline 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (2021)
	OECD Test Guideline 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2023)
	OECD Test Guideline 467: Defined Approaches for Serious Eye Damage and Eye Irritation (2022)
	In vivo:
	OECD Test Guideline 405: Acute Eye Irritation/Corrosion (2023)	(B.5)“

(ii)

v vnosu „Preobčutljivost kože“ se oddelek „In vitro“ nadomesti z naslednjim:

„In vitro:
OECD Test Guideline 442C: In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins (2023)	(B.59)
OECD Test Guideline 442D: In Vitro Skin Sensitisation Assays Addressing the AOP Key Event on Keratinocyte Activation (2022)	(B.60)
OECD Test Guideline 442E: In Vitro Skin Sensitisation: In Vitro Skin Sensitisation Assays Addressing the Key Event on Activation of Dendritic Cells on the Adverse Outcome Pathway for Skin Sensitisation (2023)	(B.71)“
OECD Test Guideline 497: Defined Approaches on Skin Sensitisation (2023)

(iii)

v vnosu „Mutagenost“ se vrstica:


	„OECD Test Guideline 487: In vitro Mammalian Cell Micronucleus Test (2016)	B.49“

nadomesti z naslednjim:


	„OECD Test Guideline 487: In vitro Mammalian Cell Micronucleus Test (2023)	(B.49)“;

(iv)

v vnosu „Lastnosti endokrinih motilcev“ se vrstici:


	„OECD Test Guideline 456: H295R Steroidogenesis Assay (2022)	B.57“
	OECD Test Guideline 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals (2020)

nadomestita z naslednjim:


	„OECD Test Guideline 456: H295R Steroidogenesis Assay (2023)	(B.57)“
	OECD Test Guideline 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals (2023)

(v)

v vnosu „Fototoksičnost“ se vrstica:

„OECD Test Guideline 498: In Vitro Phototoxicity Test Method Using the Reconstructed Human Epidermis (RhE) (2021)“

nadomesti z naslednjim:

„OECD Test Guideline 498: In Vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity test method (2023)“

(vi)

za oddelkom „Fototoksičnost“ se vstavi naslednji vnos:

„Imunotoksičnost

OECD Test Guideline 444A: In vitro immunotoxicity IL-2 Luc assay (2023)“

(c)

tabela 3 se spremeni:

(i)

v vnosu „Razgradnja“ se vrstica:

„OECD Test Guideline 316: Phototransformation of Chemicals in Water – Direct Photolysis (2008)“

nadomesti z naslednjim:

„OECD Test Guideline 316: Phototransformation of Chemicals in Water – Direct Photolysis (2023)“

(ii)

v vnosu „Učinki na organizme, ki živijo v usedlinah“ se vrstici:

	„OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment (2004)	C.27
	OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Using Spiked Water (2004)	C.28“

nadomestita z naslednjim:

	„OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Test Using Spiked Sediment (2023)	(C.27)
	OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Test Using Spiked Water (2023)	(C.28)“

(iii)

v vnosu „Lastnosti endokrinih motilcev“ se vrstica:

„OECD Test Guideline 240: Medaka Extended OneGeneration Reproduction Test (MEOGRT) (2015)

C.52“

nadomesti z naslednjim:

„OECD Test Guideline 240: Medaka Extended One Generation Reproduction Test (MEOGRT) (2023)

(C.52)“

(2)	v delu B se besedilo pod naslovom poglavij B.49 in B.57 nadomesti z naslednjim: „Popolni opis te testne metode je bil črtan. Enakovredna mednarodna testna metoda je navedena v tabeli 2 dela 0.“;

(3)	v delu C se besedilo pod naslovom poglavij C.27, C.28 in C.52 nadomesti z naslednjim: „Popolni opis te testne metode je bil črtan. Enakovredna mednarodna testna metoda je navedena v tabeli 3 dela 0.“.